????????????????????/ ??????????????:pentobarbital decreases levels of panobinostat samhälle affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Stark CYP3A4 inducers can reduce panobinostat levels ort ~70% knipa lead to treatment failure.pentobarbital will decrease the level or effect of atazanavir ort affecting hepatic/intest